Back to Search Start Over

Host CD40 Is Essential for DCG Treatment Against Metastatic Lung Cancer

Authors :
Kimihiro, Yamashita
Hiroshi, Hasegawa
Mitsugu, Fujita
Masayasu, Nishi
Tomoko, Tanaka
Akira, Arimoto
Satoshi, Suzuki
Takashi, Kamigaki
Yoshihiro, Kakeji
Source :
Anticancer research. 36(7)
Publication Year :
2016

Abstract

For the application of invariant natural killer T (iNKT) cells in cancer therapy, the CD40-CD40L interaction is indispensable in administering alpha-galactosylceramide (αGalCer). We hypothesized that CD40 plays an important role in dendritic cells (DC) pulsed with αGalCer (DCGs) in the treatment of lung metastases.Wild-type (WT) and CD40(-/-) mice were treated with DCGs isolated from WT or CD40(-/-) mice in a B16F10 lung metastases model and NK and NKT cell activity in lungs and the spleen were examined.DCG treatment improved WT mice survival but CD40(-/-) hosts received no survival benefit. Conversely, attenuation of a therapeutic effect in mice treated with CD40(-/-) DCGs was not observed. The functional activities of NK and NKT cells in DCG-treated CD40(-/-) mice were partially suppressed.Host CD40 is essential for DCG treatment to have a therapeutic effect on B16F10 lung metastases.

Details

ISSN :
17917530
Volume :
36
Issue :
7
Database :
OpenAIRE
Journal :
Anticancer research
Accession number :
edsair.pmid..........09851723d32c57299814103b7a55e6f4