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First Clinicopathologic Evidence of a Non-PSMA-Related Uptake Mechanism for
- Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(9)
- Publication Year :
- 2018
-
Abstract
- The intense accumulation of prostate-specific membrane antigen (PSMA) radioligands in salivary glands is still not well understood. It is of concern for therapeutic applications of PSMA radioligands, because therapeutic radiation will damage these glands. A better understanding of the uptake mechanism is, therefore, crucial to find solutions to reduce toxicity. The aim of this study was to investigate whether the accumulation of PSMA-targeting radioligands in submandibular glands (SMGs) can be explained with PSMA expression levels using autoradiography (ARG) and immunohistochemistry (IHC).
- Subjects :
- Glutamate Carboxypeptidase II
Submandibular Gland
Gallium Radioisotopes
Lutetium
Salivary Glands
Heterocyclic Compounds, 1-Ring
Mice
Cell Line, Tumor
Image Processing, Computer-Assisted
Organometallic Compounds
Animals
Humans
Prospective Studies
Pancreas
Gallium Isotopes
Aged
Retrospective Studies
Membrane Glycoproteins
Dipeptides
Middle Aged
Prostate-Specific Antigen
Immunohistochemistry
Magnetic Resonance Imaging
Positron-Emission Tomography
Antigens, Surface
Autoradiography
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 15355667
- Volume :
- 60
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Accession number :
- edsair.pmid..........08a551855791c4c6ab9b964460bd7e7f