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PYY is a negative regulator of bone mass and strength
- Source :
- Bone
- Publication Year :
- 2019
-
Abstract
- Objective Bone loss in anorexia nervosa and following bariatric surgery is associated with an elevated circulating concentration of the gastrointestinal, anorexigenic hormone, peptide YY (PYY). Selective deletion of the PYY receptor Y1R in osteoblasts or Y2R in the hypothalamus results in high bone mass, but deletion of PYY in mice has resulted in conflicting skeletal phenotypes leading to uncertainty regarding its role in the regulation of bone mass. As PYY analogs are under development for treatment of obesity, we aimed to clarify the relationship between PYY and bone mass. Methods The skeletal phenotype of Pyy knockout (KO) mice was investigated during growth (postnatal day P14) and adulthood (P70 and P186) using X-ray microradiography, micro-CT, back-scattered electron scanning electron microscopy (BSE-SEM), histomorphometry and biomechanical testing. Results Bones from juvenile and Pyy KO mice were longer (P<br />Highlights • Juvenile Pyy KO mice have accelerated growth and reduced bone mass. • Adult Pyy KO mice have increased bone mass and mineralisation. • Adult Pyy KO mice have increased osteoblastic bone formation and mineral apposition. • Adult Pyy KO mice have increased bone strength despite increased porosity. • Elevated PYY implicated in the pathogenesis of weight loss related osteoporosis.
- Subjects :
- Male
Mice, Knockout
Bone Development
PYY
Osteoblast
digestive, oral, and skin physiology
Osteoclasts
Organ Size
Bone and Bones
Article
Mice, Inbred C57BL
Calcification, Physiologic
Fracture
Bone Density
Cortical Bone
Bone mineral density
Animals
Osteoporosis
Female
Peptide YY
Femur
Bone Resorption
Porosity
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 18732763
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Bone
- Accession number :
- edsair.pmid..........0700ee4883fa24d8e8880a6127f97c44