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[Observation of electroacupuncture intervention on cell apoptosis and Bax and Bcl-2 expression in cerebral and myocardial tissues in cerebral ischemia rats based on 'heart-brain correlation' theory]

Authors :
Wen-Ying, Shi
Jie, Yan
Xiao-Rong, Chang
Bi-Dan, Lou
Jin-Xiang, Li
Jie, Huang
Hua, Lin
Chao, Wang
Wei, Zhang
Source :
Zhen ci yan jiu = Acupuncture research. 44(2)
Publication Year :
2019

Abstract

To compare the effect of electroacupuncture (EA) of "Neiguan" (PC6) of the Pericardium Meridian, "Shenmen" (HT7) of the Heart Meridian,"Shuigou" (GV26) of the Governor Vessel and "Zhaohai" (KI6) of the Kidney Meridian on myocardial and cerebral cell apoptosis in cerebral ischemia (CI) rats, so as to explore its mechanism underlying improvement of CI based on the theory of "Heart-brain Correlation".Forty-eight SD rats (half male and half female) were randomly divided into normal control, model, PC6, HT7, GV26 and KI6 groups (Following modeling, the cell apoptosis percentages and Bax-positive cells of both myocardial and cerebral tissues were significantly increased in the model group in comparison with the control group (EA stimulation of PC6 and HT7 can inhibit CI injury induced cell apoptosis of cerebral and myocardial tissues in CI rats, which is possibly associated with its effects in down-regulating Bax expression and up-regulating Bcl-2 expression of both myocardial and cerebral tissues.

Details

ISSN :
10000607
Volume :
44
Issue :
2
Database :
OpenAIRE
Journal :
Zhen ci yan jiu = Acupuncture research
Accession number :
edsair.pmid..........06213ce2318bb6a31b7d7e4a6d1892fd