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Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4
- Source :
- Cancer immunology research. 10(1)
- Publication Year :
- 2021
-
Abstract
- The HER3/ERBB3 receptor is an oncogenic receptor tyrosine kinase that forms heterodimers with EGFR family members and is overexpressed in numerous cancers. HER3 overexpression associates with reduced survival and acquired resistance to targeted therapies, making it a potential therapeutic target in multiple cancer types. Here, we report on immunogenic, promiscuous MHC class II-binding HER3 peptides, which can generate HER3-specific CD4
- Subjects :
- CD4-Positive T-Lymphocytes
Mice, Inbred BALB C
Receptor, ErbB-3
Histocompatibility Antigens Class II
Epitopes, T-Lymphocyte
Breast Neoplasms
Dendritic Cells
Th1 Cells
Cancer Vaccines
Survival Analysis
Tumor Burden
Mice, Inbred C57BL
Mice
Treatment Outcome
Cell Line, Tumor
Animals
Humans
Female
Amino Acid Sequence
Subjects
Details
- ISSN :
- 23266074
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer immunology research
- Accession number :
- edsair.pmid..........0607fc7a71a38ee7f7f7b21c39d200dc