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Enhancing CD8
- Source :
- Cancer cell. 32(3)
- Publication Year :
- 2016
-
Abstract
- How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the tumor microenvironment (TME) and to what degree this affects their ability to combat tumor progression remain poorly understood. Using mouse melanoma models, we report that CD8
- Subjects :
- Fatty Acids
Programmed Cell Death 1 Receptor
CD8-Positive T-Lymphocytes
Hypoxia-Inducible Factor 1, alpha Subunit
Lymphocyte Activation
Lymphocyte Activation Gene 3 Protein
Cell Hypoxia
Mice, Inbred C57BL
Oxygen
Glucose
Lymphocytes, Tumor-Infiltrating
Treatment Outcome
Antigens, CD
Stress, Physiological
Gene Knockdown Techniques
Disease Progression
Tumor Microenvironment
Animals
Humans
Female
Immunotherapy
Melanoma
Subjects
Details
- ISSN :
- 18783686
- Volume :
- 32
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer cell
- Accession number :
- edsair.pmid..........0601b4c6a690b9814e47dc4a0174cf52