Transmission of lymphocyte responsiveness to schistosomal antigens by breast feeding

Fifty normal infants were evaluated for the influence of their feeding pattern on the mother-to-child transmission of lymphocyte responsiveness to Schistosoma mansoni antigens. Positive delayed-type hypersensitivity reactions (DTH) were observed in 56% of infants who were breast-fed by infected mothers. Two out of 20 formula-fed infants born to infected mothers had positive DTH. A positive DTH was detected in only one infant out of 15 breast-fed by schistosomiasis-free mothers. These results suggest that cellular hypersensitivity to S. mansoni antigen can - at least in part - be transmitted in the colostrum/milk of infected mothers to their infants.