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In Vitro Sensitivity of Cutaneous
- Source :
- The American journal of tropical medicine and hygiene. 96(5)
- Publication Year :
- 2017
-
Abstract
- Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous. One isolate exhibited high IC50 values for almost all drugs tested. Pentamidine, which is the first-line treatment in French Guiana, showed efficacy at very low doses (mean of 0.0038 μg/mL). The concordance of the in vitro pentamidine results with the patients' clinical outcomes was 94% (K = 0.82).
- Subjects :
- Meglumine Antimoniate
Paromomycin
Phosphorylcholine
Antiprotozoal Agents
Drug Resistance
Leishmaniasis, Cutaneous
Articles
Azithromycin
Leishmania braziliensis
Meglumine
Treatment Outcome
Parasitic Sensitivity Tests
Amphotericin B
parasitic diseases
Organometallic Compounds
Humans
Leishmania guyanensis
Fluconazole
Pentamidine
Subjects
Details
- ISSN :
- 14761645
- Volume :
- 96
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The American journal of tropical medicine and hygiene
- Accession number :
- edsair.pmid..........01e1fee49aec909326ecebd684bf3421