[Effect of P53 Expression on Prognosis of Patients with Double Expressor Lymphoma]

To investigate the effect of P53 expression on prognosis of patients with double expressor lymphoma(DEL) and the interaction between the expression of MYC, BCL2 and P53 in diffuse large B-cell lymphoma(DLBCL).Eighty-eight patients with newly diagnosed DLBCL from 1st September 2012 to 31th May 2018 in Shanxi Dayi Hospital affiliated to Shanxi Medical University were selected. The expressions of MYC、BCL2、P53、CD10、BCL6、MUM and Ki-67 were tested by immunohistochemistry method. The overall survival of patients was analyzed by the Kaplan-Meier method and compared by the log-rank test. The prognostic effect of MYC, BCL2 and P53 expression was analyzed by univariate and multivariate analysis.Compared with patients without P53 expression, the patients with P53 expression had higher LDH level, higher NCCN-IPI scores, lower response to chemotherapy，poorer overall survival(OS) and a higher rate of death(P0.05). In patients who had diffuse large B-cell lymphoma associated with MYC, BCL2 expression or MYCP53 and MYC expressions have a synergistically negative prognostic effect in DLBCL patients. P53 expression augments the negative prognostic effect of MYCP53表达对双表达淋巴瘤患者预后影响的研究.研究P53表达对双表达淋巴瘤（double expressor ymphoma,DEL）患者预后的影响，以及MYC、BCL2和P53表达三者间的相互作用.选择山西医科大学附属大医院2012年9月1日至2018年5月31日经明确病理诊断的初诊DLBCL患者88例，采用免疫组织化学（IHC）技术检测淋巴组织标本MYC、BCL2、P53、CD10、BCL6、MUM1和Ki-67的表达。用Kaplan-Meier法和Log-rank检验进行生存分析和比较，利用单因素和多因素分析MYC、BCL2和P53表达对预后的影响.对比P53P53与MYC表达对DLBCL患者预后有负协同作用；P53表达加强了MYC