Back to Search Start Over

CONSULTAAUTOR Mercury, lead and cadmium in human milk in relation to diet, lifestyle habits and sociodemographic variables in Madrid (Spain)

Authors :
Garcia-Esquinas, Esther
Perez-Gomez, Beatriz
Fernández, Mario Antonio
Pérez-Meixeira, Ana María
Gil, Elisa
de Paz, Concha
Iriso, Andrés
Sanz, Juan Carlos
Astray, Jenaro
Cisneros, Margot
de Santos, Amparo
Asensio, Angel
García-Sagredo, José Miguel
García, José Frutos
Vioque, Jesus
Pollan-Santamaria, Marina
Lopez-Abente, Gonzalo
González, Maria José
Martínez, Mercedes
Bohigas, Pedro Arias
Pastor, Roberto
Aragones, Nuria
Publication Year :
2011
Publisher :
Elsevier, 2011.

Abstract

BACKGROUND: Although breastfeeding is the ideal way of nurturing infants, it can be a source of exposure to toxicants. This study reports the concentration of Hg, Pb and Cd in breast milk from a sample of women drawn from the general population of the Madrid Region, and explores the association between metal levels and socio-demographic factors, lifestyle habits, diet and environmental exposures, including tobacco smoke, exposure at home and occupational exposures. METHODS: Breast milk was obtained from 100 women (20 mL) at around the third week postpartum. Pb, Cd and Hg levels were determined using Atomic Absorption Spectrometry. Metal levels were log-transformed due to non-normal distribution. Their association with the variables collected by questionnaire was assessed using linear regression models. Separate models were fitted for Hg, Pb and Cd, using univariate linear regression in a first step. Secondly, multivariate linear regression models were adjusted introducing potential confounders specific for each metal. Finally, a test for trend was performed in order to evaluate possible dose-response relationships between metal levels and changes in variables categories. RESULTS: Geometric mean Hg, Pb and Cd content in milk were 0.53 μg L(-1), 15.56 μg L(-1), and 1.31 μg L(-1), respectively. Decreases in Hg levels in older women and in those with a previous history of pregnancies and lactations suggested clearance of this metal over lifetime, though differences were not statistically significant, probably due to limited sample size. Lead concentrations increased with greater exposure to motor vehicle traffic and higher potato consumption. Increased Cd levels were associated with type of lactation and tended to increase with tobacco smoking. CONCLUSIONS: Surveillance for the presence of heavy metals in human milk is needed. Smoking and dietary habits are the main factors linked to heavy metal levels in breast milk. Our results reinforce the need to strengthen national food safety programs and to further promote avoidance of unhealthy behaviors such as smoking during pregnancy.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......4734..c844ad896fd77b93ed9cf89d9211b726