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Synthesis, characterization and cytotoxic activity of novel Pt(II) complexes with acetylacetonate and amines
- Publication Year :
- 2013
- Publisher :
- CIRCMSB, 2013.
-
Abstract
- The new b-diketonate compounds ([Pt(O,O’-acac)(gamma-acac)(NH3)] and [Pt(O,O’-acac)(g-acac)(py)]) were chemical characterized by NMR spectroscopy and preliminary cytotoxic assays of [Pt(O,O’-acac)(g-acac)(NH3)] on cisplatin resistant MCF-7 breast cancer cell line were performed. Interestingly, [Pt(O,O’-acac)(gamma-acac)(NH3)] resulted in dose dependent inhibition of cell survival comparable to [Pt(O,O’-acac)(γ-acac)(DMS) and approximately 90-fold greater than that observed for cisplatin.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od......4034..d5043bfc562f3718796a27e007ed1a76