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Modified cyclodextrins as broad-spectrum antivirals
- Source :
- Jones, S 2020, ' Modified cyclodextrins as broad-spectrum antivirals ', Science Advances, vol. 6, no. 5, eaax9318 . https://doi.org/10.1126/sciadv.aax9318
- Publication Year :
- 2020
-
Abstract
- Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles. Here, we develop further the concept and describe cyclodextrins, modified with mercaptoundecane sulfonic acids, to mimic heparan sulfates and to provide the key nontoxic virucidal action. We show that the resulting macromolecules are broad-spectrum, biocompatible, and virucidal at micromolar concentrations in vitro against many viruses [including herpes simplex virus (HSV), respiratory syncytial virus (RSV), dengue virus, and Zika virus]. They are effective ex vivo against both laboratory and clinical strains of RSV and HSV-2 in respiratory and vaginal tissue culture models, respectively. Additionally, they are effective when administrated in mice before intravaginal HSV-2 inoculation. Lastly, they pass a mutation resistance test that the currently available anti-HSV drug (acyclovir) fails.
- Subjects :
- Antiviral, sugar, cyclodextrin, broad-spectrum
viruses
Antiviral Agents/chemical synthesis
Zika Virus/drug effects
Metal Nanoparticles/chemistry
Acyclovir/chemistry
Cyclodextrins/chemical synthesis
Mice
Gold/chemistry
Herpesvirus 2, Human/drug effects
Virus Diseases/drug therapy
Heparitin Sulfate/chemistry
Humans
Animals
Female
Herpesvirus 1, Human/drug effects
Simplexvirus/drug effects
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Jones, S 2020, ' Modified cyclodextrins as broad-spectrum antivirals ', Science Advances, vol. 6, no. 5, eaax9318 . https://doi.org/10.1126/sciadv.aax9318
- Accession number :
- edsair.od......3818..caf3af77e89e5dba46c254048d281d18