Patient perceptions of glucocorticoid side effects: a cross-sectional survey of users in an online health community

ObjectivesTo identify the side effects most important to glucocorticoid (GC) users through a survey of a UK online health community (Healthunlocked.com).DesignOnline cross-sectional survey.SettingParticipants were recruited through Healthunlocked.com, an online social network for health. ParticipantsAdults who were currently taking GCs, or had taken GCs in the past month.MethodResponders scored the importance of listed side effects from one to ten, with ten being of high importance to them. For each side effect, histograms were plotted, and the median rating and inter-quartile range (IQR) was determined. Side effects were ranked by median ranking (largest to smallest) and then IQR (smallest to largest). The scores were categorised as low (scores 1-3), medium (scores 4-7) and high (scores 8-10) importance. Results 604 responders completed the survey. Histograms of side effect scores showed a skew towards high importance for weight gain, a U-shaped distribution for CVD, diabetes, eye disease and infections, and a skew towards low importance for acne. When ranked the side effect of most importance to responders was weight gain (median score=9, IQR 6, 10) followed by insomnia and moon face with equal median score (8) and IQR (5, 10). Three serious side effects: cardiovascular disease, diabetes and infections, were ranked of lower importance overall but had wide ranging scores (median score=8, IQR 1, 10). ConclusionsThe three most highly rated side effects were not clinically serious but remained important to patients, perhaps reflecting their impact on quality of life and high prevalence. This should be taken into consideration when discussing treatment options and planning future GC safety studies.Keywords: Steroids, Side effects, Patient beliefs