Pathogenic PTPN11 variants involving the poly-glutamine Gln255-Gln256-Gln257 stretch highlight the relevance of helix B in SHP2's functional regulation

Authors :: Martinelli, S
Pannone, L
Lissewski, C
Brinkmann, J
Flex, E
Schanze, D
Calligari, P
Anselmi, M
Pantaleoni, F
Canale, Vc
Radio, Fc
Ioannides, A
Rahner, N
Schanze, I
Josifova, D
Bocchinfuso, G
Ryten, M
Stella, L
Tartaglia, M
Zenker, M
Publication Year :: 2020
Publisher :: John Wiley and Sons Inc., 2020.

Subjects :: Settore CHIM/02
ERK phosphorylation studies
in vitro phosphatase assay
Noonan syndrome
SHP2
molecular dynamics simulations
PTPN11

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