High-sensitivity Troponin T and incident heart failure in older men: British Regional Heart Study

Objective The aim of this work was to study the association of high-sensitivity troponin T (hsTnT) with incident heart failure (HF), and implications for its use in prediction models. Methods and Results In the British Regional Heart Study, 3852 men aged 60–79years without baseline HF (3165 without baseline chronic heart disease) were followed for a median of 12.6years, during which 295 incident cases of HF occurred (7.7%). A 1-SD increase in log-transformed hsTnT was associated with a higher risk of incident HF after adjusting for classic risk factors (hazard ratio [HR] 1.58, 95% confidence interval [CI] 1.42–1.77) and after additional adjustment for N-terminal pro–B-type natriuretic peptide (NT-proBNP; HR 1.34, 95% CI 1.19–1.52). The strength of the association between hsTnT and incident HF did not differ by strata of other risk factors. An hsTnT concentration of