Back to Search
Start Over
Wnt signaling and Dupuytren's disease
- Source :
- N. Engl. J. Med. 365, 307-317 (2011)
- Publication Year :
- 2011
- Publisher :
- Massachusetts Medical Society, 2011.
-
Abstract
- BACKGROUND: Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis. METHODS: We conducted a genomewide association study of 960 Dutch persons with Dupuytren's disease and 3117 controls (the discovery set) to test for association between the disease and genetic markers. We tested the 35 single-nucleotide polymorphisms (SNPs) most strongly associated with Dupuytren's disease (P
- Subjects :
- Genetic susceptibility
Contracture
Catenin
Association
Management
Expression
Variants
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- N. Engl. J. Med. 365, 307-317 (2011)
- Accession number :
- edsair.od......3474..3a3c170497e5b5d8864a9f0363d64abb