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Derivatization of Some Maleic Anhydride Containing Copolymers with Amine Functionalized Pharmaceutical Active Substances, Structural Characterizations and Biological Activities
- Publication Year :
- 2015
- Publisher :
- MARMARA UNIV, FAC PHARMACY, 2015.
-
Abstract
- WOS: 000361222900006<br />Poly(maleic anhydride-co-styrene) (MAST), poly(maleic anhydride-co-vinyl acetate) (MAVA), poly(maleic anhydride-co-methyl methacrylate) (MAMMA), poly(maleic anhydride-co-allyl phenyl ether) (MAAFE) and poly(maleic anhydride-alt-acrylic acid) (MAAA) copolymers were synthesized by free radical chain polymerization reaction. Modification/derivatization of the copolymers with active pharmaceutical ingredients, in amine form (-NH2), was performed by the ring opening reaction. Structural characterization of the copolymers and the conjugated products was carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (H-1-NMR). The FTIR and H-1-NMR spectra, confirmed that pharmaceutically active agents were covalently bonded to the MAVA copolymer in a succesfull manner. Furthermore cytotoxicity on healthy fibroblast cell lines, antiproliferative activity on cancer cell lines and antibacterial activity on bacterial strains were also investigated in-vitro for synthesized conjugates. MAVA copolymer was also selected the most suitable carrier for modification/derivaritization process by comparing its affinity to the pharmaceutically active agents.
Details
- Language :
- Turkish
- Database :
- OpenAIRE
- Accession number :
- edsair.od......3104..03e530ec2e3a4a9f44d85aa5e4cfc4ea