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Discovery and mechanisms of host defense to oncogenesis: Targeting the β-defensin-1 peptide as natural tumor inhibitor

Authors :
Q. Sun, Carrie
Arnold, Rebecca
Hsieh, Chia-Ling
Dorin, Julia R.
Lian, Fei
Li, Zhenghong
Petros, John A.
Source :
Q. Sun, C, Arnold, R, Hsieh, C-L, Dorin, J R, Lian, F, Li, Z & Petros, J A 2019, ' Discovery and mechanisms of host defense to oncogenesis: Targeting the β-defensin-1 peptide as natural tumor inhibitor ', Cancer Biology and Therapy . https://doi.org/10.1080/15384047.2018.1564564
Publication Year :
2019

Abstract

Human beta-defensin-1 (hBD-1) is one of a number of small cationic host-defense peptides. Besides its well-known broad-spectrum antimicrobial function, hBD-1 has recently been identified as a chromosome 8p tumor-suppressor gene. The role of hBD-1 in modulating the host immune responseto oncogenesis, associated with cell signaling and potential therapeutic applications, has become increasingly appreciated over time. In this study, multiple approaches were used to illustrate hBD-1 antitumor activities. Results demonstrate that hBD-1 peptide alters human epidermal growth factor receptor2 (HER2) signal transduction and represses retroviral-mediated transgene expression in cancer cells. Loss of orthologous murine defense-1 (mBD1) in mice enhances nickel sulfate-induced leiomyosarcoma andcauses mouse kidney cells to exhibit increased susceptibility to HPV-16 E6/7-induced neoplastic transformation. Furthermore, for the first time, a novel function of the urine-derived hBD-1 peptide was discovered to suppress bladder cancer growth and this may lead to future applications in the treatmentof malignancy.

Details

Language :
English
Database :
OpenAIRE
Journal :
Q. Sun, C, Arnold, R, Hsieh, C-L, Dorin, J R, Lian, F, Li, Z & Petros, J A 2019, ' Discovery and mechanisms of host defense to oncogenesis: Targeting the β-defensin-1 peptide as natural tumor inhibitor ', Cancer Biology and Therapy . https://doi.org/10.1080/15384047.2018.1564564
Accession number :
edsair.od......3094..ab91463d01bbacfd388462a7ddb4013b