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TGFβR signalling determines CD103+CD11b+ dendritic cell development in the intestine
- Source :
- Bain, C C, Montgomery, J, Scott, C L, Kel, J M, Girard-Madoux, M J H, Martens, L, Zangerle-Murray, T F P, Ober-Blobaum, J, Lindenbergh-Kortleve, D, Samsom, J N, Henri, S, Lawrence, T, Saeys, Y, Malissen, B, Dalod, M, Clausen, B E & Mowat, A M 2017, ' TGFβR signalling determines CD103 + CD11b + dendritic cell development in the intestine ', Nature Communications, vol. 8, 620 . https://doi.org/10.1038/s41467-017-00658-6
- Publication Year :
- 2017
-
Abstract
- CD103+CD11b+ dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFβR1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103+CD11b+ DCs and a reciprocal increase in the CD103−CD11b+ dendritic cell subset. Transcriptional profiling identifies markers that define the CD103+CD11b+ DC lineage, including CD101, TREM1 and Siglec-F, and shows that the absence of CD103+CD11b+ DCs in CD11c-Cre.Tgfbr1 fl/fl mice reflects defective differentiation from CD103−CD11b+ intermediaries, rather than an isolated loss of CD103 expression. The defect in CD103+CD11b+ DCs is accompanied by reduced generation of antigen-specific, inducible FoxP3+ regulatory T cells in vitro and in vivo, and by reduced numbers of endogenous Th17 cells in the intestinal mucosa. Thus, TGFβR1-mediated signalling may explain the tissue-specific development of these unique DCs.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Bain, C C, Montgomery, J, Scott, C L, Kel, J M, Girard-Madoux, M J H, Martens, L, Zangerle-Murray, T F P, Ober-Blobaum, J, Lindenbergh-Kortleve, D, Samsom, J N, Henri, S, Lawrence, T, Saeys, Y, Malissen, B, Dalod, M, Clausen, B E & Mowat, A M 2017, ' TGFβR signalling determines CD103 + CD11b + dendritic cell development in the intestine ', Nature Communications, vol. 8, 620 . https://doi.org/10.1038/s41467-017-00658-6
- Accession number :
- edsair.od......3094..8adc0ed4e62072b4d6d0c8d2b54a00ee