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Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
- Source :
- Edgar, J M, McLaughlin, M, Yool, D, Zhang, S C, Fowler, J H, Montague, P, Barrie, J A, McCulloch, M C, Duncan, I, Garbern, J, Nave, K-A & Griffiths, I R 2004, ' Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. ', Journal of Cell Biology, vol. 166, no. 1, pp. 121-31 .
- Publication Year :
- 2004
-
Abstract
- Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis.
- Subjects :
- Myelin Sheath/metabolism
Heterozygote
Time Factors
Reverse Transcriptase Polymerase Chain Reaction
Cell Membrane/metabolism
Blotting, Western
Spastic Paraplegia, Hereditary/pathology
Biological Transport
Axons/metabolism
Immunohistochemistry
Spinal Cord/pathology
Mice, Mutant Strains
Disease Models, Animal
Mice
Oligodendroglia/metabolism
Phenotype
nervous system
Cytoskeleton/metabolism
Spastic Paraplegia, Hereditary/genetics
Animals
Spastic Paraplegia, Hereditary/metabolism
Alleles
Optic Nerve/metabolism
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Edgar, J M, McLaughlin, M, Yool, D, Zhang, S C, Fowler, J H, Montague, P, Barrie, J A, McCulloch, M C, Duncan, I, Garbern, J, Nave, K-A & Griffiths, I R 2004, ' Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. ', Journal of Cell Biology, vol. 166, no. 1, pp. 121-31 .
- Accession number :
- edsair.od......3094..3b1649f675777871b8650c4986ddc650