Non-surgical periodontal treatment impact on biomarkers levels of bone metabolism in saliva

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-07T14:55:29Z No. of bitstreams: 1 TESE_FINAL_TATIANE_FLOR_COELHO_DE_SOUZA_BREVES_BEILER.pdf: 2166086 bytes, checksum: c59f0139075b819c7c5d7afe8bd3564a (MD5) Made available in DSpace on 2021-01-07T14:55:29Z (GMT). No. of bitstreams: 1 TESE_FINAL_TATIANE_FLOR_COELHO_DE_SOUZA_BREVES_BEILER.pdf: 2166086 bytes, checksum: c59f0139075b819c7c5d7afe8bd3564a (MD5) Previous issue date: 2019-07-05 The aim of this study was to evaluate the effect of non-surgical periodontal therapy, after 1 year, on the salivar expression of bone metabolism markers: TNF-α, SOST, PTH, OPG, OPN, OC, Leptin, IL-6, IL-1β and FGF-23; in patients with generalized chronic periodontitis. Fifteen patients with generalized chronic periodontitis (mean age 56.0 ± SD 9.6 years) were included in this study. Fifteen patients with gingivitis (mean age 39.7 ± SD 4.4 years) were used as controls. Clinical evaluation parameters including probing pocket depth (PD), clinical attachment level (CAL), visible plaque index (VPI), gingival index bleeding (GI) and bleeding on probing (BOP) were used. Non-stimulated whole saliva was collected (1ml) and frozen at -70°C for further analysis. Patients from both groups received non-surgical periodontal treatment. All data were collected in 3 visits in the group with periodontitis (baseline, 6 months and 1 year); and in 2 visits in the group with gingivitis (baseline and 1 year). The biomarkers expression were evaluated through multiplex technology. In the group with periodontitis, there was a significant reduction of the parameters % PD ≥ 6 (p