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The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology
- Source :
- Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
- Publication Year :
- 2019
- Publisher :
- BioMed Central Ltd., 2019.
-
Abstract
- Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. Several FOX gene subgroup transcriptional disturbances, affecting numerous complex molecular cascades, have been linked to a wide range of cancer types highlighting their potential usefulness as molecular biomarkers. At least 14 FOX subgroups have been related to CRC pathogenesis, thereby underlining their role for diagnosis, prognosis and treatment purposes. This manuscript aims to provide, for the first time, a comprehensive review of FOX genes' roles during CRC pathogenesis. The molecular and functional characteristics of most relevant FOX molecules (FOXO, FOXM1, FOXP3) have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis. Potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included. Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. © 2019 The Author(s).
- Subjects :
- Pdpk1 gene
Apoptosis
Cancer cell
Review
Gene editing
Akt2 gene
Clinical research
Molecular aetiology
Cancer growth
Dna binding
Pathology
Tumor suppressor gene
Cell cycle g1 phase
Cell proliferation
Cell cycle g2 phase
Fox gene
Gene expression regulation
Cell cycle s phase
Cancer diagnosis
Cell motion
Transcription regulation
Prognosis
Lymphocytic infiltration
Tumor microenvironment
Foxo gene
Transcription factor foxo
Human
Science
Oncoprotein
Cancer research
Cell cycle m phase
Colorectal neoplasms
Forkhead transcription factors
Protein phosphorylation
Cell movement
Regulatory t lymphocyte
Crispr-cas9 system
Genetics
Animals
Humans
Colorectal tumor
Forkhead transcription factor
Animal
Immunity
Colon carcinogenesis
Foxm1 gene
Nonhuman
Colorectal cancer
neoplastic
Akt1 gene
Binding affinity
Foxp3 gene
Cisplatin
Cell cycle regulation
Gene function
Forkhead box protein m1
Transcription factor foxp3
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
- Accession number :
- edsair.od......3056..daac4c402cff371116d78ee4ef614591