Fun????o pulmonar e for??a muscular respirat??ria de idosos com Doen??a de Parkinson em est??gio inicial: estudo observacional

Submitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2019-03-11T12:53:58Z No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2019-03-11T12:58:26Z (GMT) No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2019-03-11T12:58:26Z (GMT). No. of bitstreams: 2 Reprodu????o N??o Autorizada.pdf: 47716 bytes, checksum: 0353d988c60b584cfc9978721c498a11 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2019-02-22 CAPES - Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior 92 99275-7872 Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in the world. It is a disorder of the non-contagious and nonfatal movement caused by the progressive loss of the ventrolateral cells of the compact part of the black substance of the midbrain, which leads to three cardinal signs: rest tremor, stiffness and bradykinesia. Although the scientific research mainly addresses neuromotor signs, there are other functional damages, and the consequences of ventilatory dysfunction are the main cause of death in this population. Objective: To analyze pulmonary function and respiratory muscle strength (FMR) of elderly patients with PD at an early stage. Method: An observational study evaluating the degree of dysfunction related to the disease through the modified Hoehn & Yahr scale, FMR by manovacuometry, and pulmonary volumes and capacities by spirometry. FMR and lung function were evaluated in the on and off period of levodopa (L-Dopa). The results were presented through graphs and tables, with simple absolute frequencies and relative to the categorical data. For the analysis of the quantitative data, when the normality hypothesis was accepted using the Shapiro-Wilk test, the mean and the standard deviation (SD) were calculated. When the normality hypothesis was rejected, it was decided to calculate the median and the interquartile range (IIQ). In the comparison of means, the t-student test was applied, and in the case of the dependent variables the paired t-student test. In the comparison of medians, the Mann-Whitney test for the independent variables was applied, and Wilcoxon for dependent variables. The Minitab version 17 program was used for Windows and the level of significance in the statistical tests was 5%. Results: Elderly patients with early-stage PD had a higher prevalence of ventilatory disorder than their controls, mainly the restrictive disorder. There was no respiratory muscle weakness and no difference between the respiratory muscle strength of the elderly with PD in relation to their controls, matched by gender, age and body mass index. The on-off period of L-Dopa didn???t change the analyzed variables. Conclusion: Elderly patients with PD present ventilatory disorders, even in the early stages of the disease, being the restrictive disorder the most prevalent. L-Dopa does not change the analyzed variables. A Doen??a de Parkinson (DP) ?? a segunda doen??a neurodegenerativa mais prevalente no mundo. ?? uma desordem do movimento n??o contagiosa e n??o fatal causada pela perda progressiva das c??lulas ventrolaterais da parte compacta da subst??ncia negra do mesenc??falo, que leva a tr??s sinais cardeais: tremor de repouso, rigidez e bradicinesia. Apesar das pesquisas cient??ficas abordarem, principalmente, os sinais neuromotores, existem outros preju??zos funcionais, sendo as consequ??ncias da disfun????o ventilat??ria a principal causa de morte nesta popula????o. Objetivo: Analisar a fun????o pulmonar e a for??a muscular respirat??ria (FMR) de idosos com DP em est??gio inicial. M??todo: Estudo observacional que avaliou o grau de disfun????o relacionado ?? doen??a por meio da escala de Hoehn & Yahr modificada, a FMR por manovacuometria e os volumes e capacidades pulmonares pela espirometria. A FMR e a fun????o pulmonar foram avaliadas no per??odo on e off da levodopa (L-Dopa). Os resultados foram apresentados por meio de gr??ficos e tabelas, com frequ??ncias absolutas simples e relativas para os dados categ??ricos. Para a an??lise dos dados quantitativos, quando aceita a hip??tese de normalidade por meio do teste de Shapiro-Wilk, foi calculada a m??dia e o desvio padr??o (DP). Quando rejeitada a hip??tese de normalidade optou-se por calcular a mediana e o intervalo interquartil (IIQ). Na compara????o das m??dias foi aplicado o teste t-student, sendo no caso das vari??veis dependentes o teste t-student pareado. Na compara????o das medianas foi aplicado o teste de Mann-Whitney para as vari??veis independentes, e Wilcoxon para vari??veis dependentes. Foi utilizado o programa Minitab vers??o 17 para Windows e o n??vel de signific??ncia fixado nos testes estat??sticos foi de 5 %. Resultados: Os idosos com DP em est??gio inicial da doen??a apresentaram maior preval??ncia de dist??rbio ventilat??rio que seus controles, principalmente o dist??rbio restritivo. N??o houve fraqueza muscular respirat??ria e nem diferen??a entre a FMR dos idosos com DP em rela????o a seus controles, pareados por sexo, idade e ??ndice de massa corporal. O per??odo on e off da L-Dopa n??o alterou as vari??veis analisadas. Conclus??o: Idosos com DP apresentam dist??rbios ventilat??rios, mesmo em est??gios iniciais da doen??a, sendo o dist??rbio restritivo o mais prevalente. A L-Dopa n??o alterou a vari??veis analisadas. Per??odo de Embargo: 07/03/2019 - 26/04/2021