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Efeito analgésico e anti-inflamatório do extrato aquoso das folhas de trevo-roxo (Scutellaria agrestis A. St.-Hil. Ex Benth. - Lamiaceae) em roedores
- Source :
- Repositório Institucional do INPA, Instituto Nacional de Pesquisas da Amazônia (INPA), instacron:INPA
- Publication Year :
- 2014
- Publisher :
- Revista Brasileira de Plantas Medicinais, 2014.
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Abstract
- The Scutellaria agrestis is used by Amazonas riverine communities, especially for otitis externa topical treatment, by using the crude extract obtained by maceration. This study aimed to investigate the preliminary phytochemical profile, the safety/toxicity and the analgesic, anti-inflammatory and antiedematogenic activities of the aqueous extract of the S. agrestis leaves. Eighty individuals were collected at the Nilton Lins University medicinal garden, Manaus, Brazil. The phytochemical profile was obtained through a plant drug survey for cyanogenic heterosides, terpenes, alkaloids and phenolic compounds. The extract safety was evaluated by acute toxicity test. Analgesic and anti-inflammatory activities were accessed using formalin test in mice and the antiedematogenic activity, using paw edema test in mice. We detected phenolic (hydrolysable tannins, coumarins and several classes of flavonoids) and terpenoid (free steroids, saponins) metabolites. We could not establish LD50because no animals died during the acute toxicity test, probably because of the absence of cyanogenic glycosides on the composition of the extract. However, we found that the extract is slightly toxic as animal spasms were observed in the first hour of the test. The extract showed significant analgesic and anti-inflammatory activity on the formalin test (30, 100 and 300 mg/kg p.o.), and the highest dose result was equivalent to the standard drug (Fentanyl). However, no significant antiedematogenic effect was observed during the paw edema test. The results obtained in this study provide preliminary scientific basis about the safety and analgesic/anti-inflammatory actions of the aqueous extract of S. agrestis, which indicates that this species is a promising option for further in vitro and in vivo pharmacological studies.
- Subjects :
- Antiedematogenic Activity
Phytochemistry
Mouse
Scutellaria
Animals Model
Scutellaria Agrestis A Extarct
Nonhuman
Plant Extract
Toxicity Testing
Unclassified Drug
Paw Edema
Terpene
Alkaloid
Antiinflammatory Activity
Analgesic Activity
Controlled Study
Phenol Derivative
Plant Medicinal Product
External Otitis
Cyanogenic Heteroside
Animals Experiment
Biological Activity
Subjects
Details
- Language :
- Portuguese
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional do INPA, Instituto Nacional de Pesquisas da Amazônia (INPA), instacron:INPA
- Accession number :
- edsair.od......3056..a5e6ea5973441d1ab2bfee10d795715f