Ação antiobesidade da suplementação com ômega-3 em ratos wistar

Made available in DSpace on 2022-06-22T23:55:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-30 Obesity and Its co morbidity has become world endemic health problem. Among several triggers to this condition, evolution in diet composition with large amounts intake of energetic foods, added to limited physical activities due to the modern people habits, are notables factors. Change in ratio omega-6/omega-3 fatty acids intake is an important obesity cause and can make the co morbidity become worst. Many researches evidence the role of the fatty acids omega-6/ômega3 ratio as effective health promoter by, modulating its bio-active derivatives; the eicosanoids and cytokines. The aim of this study is to evidence the anti-obesity effect of a diet supplementation with omega-3 fatty acids, and, specific aims are following up rats corporal weight, adipocytes size and blood levels of total cholesterol, high density lipoprotein (HDL) and triglycerides. This was an experimental study with five Wistar male rats groups (n=6), with body weight upper 260g. One group was euthanized at day one; two groups received intake of water by gavage during 45 and 90 days, respectively, and two groups received intake of 0,1mg/kg/weigh/day of high purified omega-3 (EPA 350 mg/ml + DHA 220 mg/ml) for 45 and 90 days. All animals received intake of water and food at libitum during the experience. .The results showed decreasing in blood total cholesterol, and triglycerides levels (p