HOXA9 mRNA expression in pituitary adenomas

Purpose: Pituitary adenoma (PA) is an intracranial tumor with the reported prevalence rate of 16.7% [1]. The aim of the present study was to examine the possible involvement of HOXA9 mRNA expression in recurrence and invasiveness of PA. Methodology: The study was carried out at the Department of Ophthalmology and Department of Neurosurgery, Lithuanian University of Health Sciences. The restrospective analysis of MRI data was conducted by an experienced radiologist. HOXA9 mRNA values were investigated in 50 PAs and were normalized to the values of β-actin and GAPDH mRNA, which were used as internal controls. Results: We found no expression of HOXA9 in PA tumors, while the reference genes of β-actin and GAPDH were successfully expressed, indicating that the cDNA synthesis was successful. Conclusions. Our study suggests that HOXA9 mRNA expression is not associated with PA invasiveness and recurrence.