The role of methadone in the terminals of patients with pain

Methadone is a relatively safe and efficient synthetic opioid analgesic with long lasting effect which is particularly useful in the treatment of pain in terminal patients . To draft pharmacodynamics , pharmacokinetics , drug interactions , clinical use , dosage rules , the negative effects of methadone and its advantages over morphine . A review of relevant literature on the use of methadone in the treatment of terminal patients' pain and meta- analyzes were conducted .