EBV-Associated Hemophagocytic Lymphohistiocytosis (HLH): A Case Report

Haemophagocytic syndrome (HPS) or Haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and natural killer cells. A 44-year-old man with hemophagocytic lymphohistiocytosis (HLH) triggered by Epstein–Bar virus (EBV) infection. The patient presented with persistent high-grade fever, deep jaundice, pancytopenia with sepsis, and acute liver injury. Laboratory results confirmed pancytopenia, transaminitis, and hyperbilirubinemia, as well as elevations in ferritin, triglycerides, and C-reactive protein. A bone marrow biopsy confirmed HLH, as well as EBV-DNA PCR test, was also positive.