Correlation of TNF-?? between lesional swab and peripheral blood of mononuclear cell of recurrent aphthous stomatitis patient

Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease in human. This disease affect 20-25% of population. The etiology remains unclear, but some of cytokine such as TNF-?? is suspected to contribute in the pathogenesis of RAS. TNF-?? is commonly measured by PBMC and lesional biopsy. These are invasive method and high skilled requirement. Another study used lesional swab to measure this cytokine without correlating the result with TNF-?? measured by PBMC level. This study aimed to asses TNF-?? level correlation between lesional swab and PBM of RAS patients. The study involved 10 subjects by inclusion criteria. Subjects have lesion swab and PBMC examined. Samples were analyzed by ELISA method. There is a correlation between lesional swab and PBMC of TNF-?? level RAS patients but this correlation did not statistically significant.