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Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods
- Publication Year :
- 2021
-
Abstract
- of thesis Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods author: MUDr. Klára Labská supervisor: doc. MUDr. Vilma Marešová, CSc. In recent years, the diagnosis of neuroinfections has undergone a shift towards molecular biology methods. Our research focused on the predictive value of the capture of herpesvirus (HV) DNA in cerebrospinal fluid. In the first study, we examined the presence of DNA neurotropic herpes viruses (HSV1, HSV2, VZV and HHV6) in cerebrospinal fluid in immunocompetent patients with laboratory-confirmed tick-borne meningoencephalitis and enterovirus meningitis and meningoencephalitis. The control group consisted of patients with proven absence of an inflammation in the cerebrospinal fluid. Patients were followed for 6 months. The course of the disease and its consequences, including laboratory tests, were compared between groups of patients with and without the presence of HV DNA. In the second study, we tried to demonstrate the presence of HSV1 DNA in cerebrospinal fluid during its symptomatic reactivation in patients with purulent meningitis. In our group of immunocompetent patients with non-purulent inflammation in the cerebrospinal fluid, the proportion of HV DNA positive patients reached 7.5% (13 out of 173), we also...
- Subjects :
- Herpes simplex virus 1
klíšťová meningoencefalitida
enteroviral meningoencephalitis
tick-borne encephalitis
Human betaherpesvirus 6A
cerebrospinal fluid
Human betaherpesvirus 6B
enterovirová meningoencefalitida
Herpes simplex virus typ 2
Herpes simplex virus typ 1
Varicella zoster virus
mozkomíšní mok
Lidský herpetický virus 6 typ A
metody amplifikace virových nukleových kyselin
Lidský herpetický virus 6 typ B
nucleic acid amplification tests
Varicella-zoster virus
Herpes simplex virus 2
Subjects
Details
- Language :
- Czech
- Database :
- OpenAIRE
- Accession number :
- edsair.od......2186..a5b07bcfa50897b62c7e14183b771ad3