Comparison of surface ferritin with levels of CRP and erythrocyte sedimentation rate as markers of acute-phase inflammation

The aim of the study is to compare the levels of ferritin, CRP and the rate of erythrocyte sedimentation. Ferritin and CRP belong to the acute phase proteins that are formed in increased levels in inflammatory conditions and certain diseases. CRP is one of the most important markers of acute phase inflammation for high sensitivity, it is increasing hours after the onset of the acute phase reaction and rises more than a hundred times during the first days. CRP was measured on a Beckman Coulter AU 680 analyzer using the reaction of antigen-antibody and photometric measurements. The ferritin measurement on the Architect analyzer is a two-stage immunoassay of the immunological chemiluminescent microparticle using. The resulting reaction is measured in the optical system. Examination of the rate of erythrocyte sedimentation is frequent, although not specific to a particular disease. However, it can be used in diagnosing or monitoring of the effect therapy efficiency. The principle of measuring on Alifax Test analyzer is monitoring the aggregate capacity of red cells through optical density. These three parameters were measured by 1000 patients, the ratios of all measured values were calculated and compared with each other by means of linear regression graphs and the calculated correlation coefficients. The correlation coefficients have shown a low degree of dependence between ferritin and CRP and between CRP and age. The medium degree of dependence was proofed between ferritin and ESR parameters, between CRP and ESR and between age and ferritin, and age and ESR. All samplies were performed lege artis according to the instructions of the standard operating procedure of the company synlab czech, s.r.o. After collecting, these samples were measured in the laboratory synlab czech, s.r.o., Vrbenská 197/23, České Budějovice.