Xenobiotika v potravinách a jejich vliv na lidský organismus

(Xenobiotics in food end their effects on the human organism) One of the exposure pathways to xenobiotics in humans is food intake. Most of xenobiotics are lipophilic substances cumulating in the organism, especially in the adipose tissue. If their intake is long-term and excessive, they have negative impact on human health. Eating habits, identification, analysis, and management of risks stemming from foods are important from a prevention perspective. The adipose tissue influences the distribution and especially accumulation of xenobiotics in the organism. Whether substances stored in the adipose tissue are able to affect adipogenesis and physiological functions, remains unclear. Since obesity-related dysfunctional and inflamed adipose tissue is associated with systemic inflammation, ectopic fat deposition, and multiorgan dysfunction, resulting in cardiometabolic complications of obesity; this knowledge would be immensely valuable. The study focused on the basic pathophysiological mechanisms at the level of adipocytes, specifically, the study of risk and protective factors. From preventive factors, the effect of phytoprotective substances with antioxidative potential was studied. Among the risk factors, we concentrated on the impact of persistent organic pollutants (POP's). We observed exposure to...