Increased hydrolysis of oximino-β-lactams by CMY-107, a Tyr199Cys mutant form of CMY-2 produced by Escherichia coli

Authors :: Kotsakis, S.D. Miriagou, V. Vetouli, E.E. Bozavoutoglou, E. Lebessi, E. Tzelepi, E. Tzouvelekis, L.S.
Publication Year :: 2015
Abstract: The cephalosporinase CMY-107, a Tyr199Cys mutant form of CMY-2 encoded by an IncI self-transferable plasmid carried by an Escherichia coli clinical strain, was characterized. The enzyme hydrolyzed oximino-cephalosporins and aztreonam more efficiently than CMY-2 did. © 2015, American Society for Microbiology. All Rights Reserved.

Subjects :: parasitic diseases
chemical and pharmacologic phenomena
bacterial infections and mycoses
therapeutics
complex mixtures

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