Wilms tumour event-free and overall survival in Southern and Eastern Europe: Pooled analyses of clinical data from four childhood cancer registries (1999–2017)

Authors :: Doganis, D. Zborovskaya, A. Trojanowski, M. Zagar, T. Bouka, P. Baka, M. Moschovi, M. Polychronopoulou, S. Papakonstantinou, E. Tragiannidis, A. Stiakaki, E. Dana, H. Stefanaki, K. Strantzia, K. Kochubinsky, D. Marciniak, P. Avcin, S. Antoniadi, K. Dessypris, N. Petridou, E.T.
Publication Year :: 2019
Abstract: Background: Wilms tumour (WT) management represents a success story in pediatric oncology. We aimed to assess, for the first time, the event-free survival (EFS) vs. overall survival (OS) in Southern and Eastern Europe (SEE) using harmonised clinical data collected by childhood cancer registries and to identify respective prognostic factors. Methods: From 1999 to 2017, data for incident WT cases aged 0–14 years from 3 nationwide (Greece, Belarus and Slovenia) and one regional (Greater Poland) SEE registries were collected following common coding. Kaplan–Meier curves were constructed, and EFS vs. OS values were derived from Cox proportional hazard models by study variables. Results: A total of 338 WT cases (45.6% males; median age, 3.19 years; age

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