Anthropometric factors and risk of endometrial cancer: The European prospective investigation into cancer and nutrition

Authors :: Friedenreich, C. Cust, A. Lahmann, P.H. Steindorf, K. Boutron-Ruault, M.-C. Clavel-Chapelon, F. Mesrine, S. Linseisen, J. Rohrmann, S. Boeing, H. Pischon, T. Tjønneland, A. Halkjær, J. Overvad, K. Mendez, M. Redondo, M.L. Garcia, C.M. Larrañaga, N. Tormo, M.-J. Gurrea, A.B. Bingham, S. Khaw, K.-T. Allen, N. Key, T. Trichopoulou, A. Vasilopoulou, E. Trichopoulos, D. Pala, V. Palli, D. Tumino, R. Mattiello, A. Vineis, P. Bueno-de-Mesquita, H.B. Peeters, P.H.M. Berglund, G. Manjer, J. Lundin, E. Lukanova, A. Slimani, N. Jenab, M. Kaaks, R. Riboli, E.
Publication Year :: 2007
Abstract: Objective: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m2) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI ≥ 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of ≥88 cm vs.

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