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Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis

Authors :
Ikonomidis, I. Tzortzis, S. Lekakis, J. Paraskevaidis, I. Andreadou, I. Nikolaou, M. Kaplanoglou, T. Katsimbri, P. Skarantavos, G. Soucacos, P. Kremastinos, D.Th.
Publication Year :
2009

Abstract

Objective: Inhibition of interleukin-1 activity improves nitro-oxidative stress, endothelial and coronary function. The authors investigated (a) the association of nitro-oxidative stress and endothelial function with myocardial deformation, (b) the effects of anakinra, an interleukin-1a receptor antagonist on myocardial deformation in patients with rheumatoid arthritis (RA). Methods: The authors compared 46 RA patients to 23 normal controls. 23 patients received anakinra (150 mg subcutaneously once daily) and 23 patients a 5-mg increase of prednisolone dose for 30 days. At baseline and post-treatment this study assessed (a) the left ventricular (LV) longitudinal, circumferential and radial strain and strain rate, using speckle tracking echocardiography, (b) the coronary flow reserve (CFR), (c) the flowmediated endothelial-dependent dilation of the brachial artery (FMD) and (d) nitrotyrosine (NT) and malondialdehyde blood levels. Results: Patients had impaired baseline myocardial deformation indices compared to controls (p

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......2127..25cd476c6453460ec4b49599e1925d3c