Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Authors :: Franke, A. Balschun, T. Sina, C. Ellinghaus, D. Häsler, R. Mayr, G. Albrecht, M. Wittig, M. Buchert, E. Nikolaus, S. Gieger, C. Wichmann, H.E. Sventoraityte, J. Kupcinskas, L. Onnie, C.M. Gazouli, M. Anagnou, N.P. Strachan, D. McArdle, W.L. Mathew, C.G. Rutgeerts, P. Vermeire, S. Vatn, M.H. Krawczak, M. Rosenstiel, P. Karlsen, T.H. Schreiber, S.
Publication Year :: 2010
Abstract: We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively). © 2010 Nature America, Inc. All rights reserved.

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