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Opposing age-related trends in absolute and relative risk of adverse health outcomes associated with out-of-office blood pressure

Authors :
Li, Y. Thijs, L. Zhang, Z.-Y. Asayama, K. Hansen, T.W. Boggia, J. Björklund-Bodegård, K. Yang, W.-Y. Niiranen, T.J. Ntineri, A. Wei, F.-F. Kikuya, M. Ohkubo, T. Dolan, E. Hozawa, A. Tsuji, I. Stolarz-Skrzypek, K. Huang, Q.-F. Melgarejo, J.D. Tikhonoff, V. Malyutina, S. Casiglia, E. Nikitin, Y. Lind, L. Sandoya, E. Aparicio, L. Barochiner, J. Gilis-Malinowska, N. Narkiewicz, K. Kawecka-Jaszcz, K. Maestre, G.E. Jula, A.M. Johansson, J.K. Kuznetsova, T. Filipovský, J. Stergiou, G. Wang, J.-G. Imai, Y. O'Brien, E. Staessen, J.A.
Publication Year :
2019

Abstract

Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (≤60, 61-70, 71-80, and >80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......2127..07df8432b7f5b9fb5ab0f43915f52735