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ESAC Opinion on the EURL ECVAM Eye Irritation Validation Study (EIVS) on EpiOcular™ EIT and SkinEthic™ HCE and a related Cosmetics Europe study on HPLC/UPLC-spectrophotometry as an alternative endpoint detection system for MTT-formazan

Authors :
CARMICHAEL Neil
BORLAK Jürgen
CARNEY Edward
CLEWELL III Harvey
COSTA Lucio
KEJLOVÁ Kristina
KIRKLAND David
KOPP-SCHNEIDER Annette
KRÄTKE Renate
LEHR Claus-Michael
NAVAS Jose M
PIERSMA Aldert
RICHMOND Jon
ROGGEN Erwin
SESARDIC Thea
MARUNOUCHI Tohru
MERRILL Jill
VIEGAS BARROSO JOAO FILIPE
Publication Year :
2016
Publisher :
Publications Office of the European Union, 2016.

Abstract

ESAC, the EURL ECVAM Scientific Advisory Committee, advises EURL ECVAM on scientific issues. Its main role is to conduct independent peer review of validation studies of alternative test methods and to assess their scientific validity for a given purpose. The committee reviews the appropriateness of study design and management, the quality of results obtained and the plausibility of the conclusions drawn. ESAC peer reviews are formally initiated with a EURL ECVAM Request for ESAC Advice, which provides the necessary background for the peer-review and establishes its objectives, timelines and the questions to be addressed. The peer review is normally prepared by specialised ESAC Working Groups. These are typically composed of ESAC members and other external experts relevant to the test method under review. These experts may be nominated by ESAC, EURL ECVAM and partner organisations within the International Cooperation on Alternative Test Methods (ICATM). ESAC ultimately decides on the composition of these Working Groups. ESAC's advice to EURL ECVAM is formally provided as 'ESAC Opinions' and 'Working Group Reports' at the end of the peer review. ESAC may also issue Opinions on other scientific issues of relevance to the work and mission of EURL ECVAM but not directly related to a specific alternative test method. The ESAC Opinion expressed in this report relates to the peer-review of the BASF-coordinated Performance Standards-based validation of the LuSens test method for skin sensitisation testing.<br />JRC.F.3-Chemicals Safety and Alternative Methods

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......1739..bc6aad08cf30f3ed23ad47b46bafbe0a