Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat

Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central opioid system has been implicated in regulating the stress response in rodents [2]. The objective of this study was to examine the effects of acute swim stress, and OB, alone or in combination, on opioid receptors and the precursors for their endogenous ligands in a number of brain regions implicated in stress/depression. This abstract is financially supported by an educational grant from the Strategic Partnership Programme Grant from Science Foundation Ireland and Alkermes, Inc. (14/SPP/B3051). non-peer-reviewed 2020-12-13