Synthesis of a cysteine protease inhibitor with a clickable moiety and its derivation into a potential activity based probe

Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020 This work is focused on the design and development of a new chemical probe derived from a new cysteine protease inhibitor. The three main parts of the inhibitor are a warhead with an epoxyketone moiety, a linker with two leucines and an azidoacetyl moiety which can be modified by adding a tag through a “click” reaction. Due to the circumstances the experimental research has not been completed yet but most of the steps of the synthesis were performed. However, from the experimental work performed some valuable information and several conclusions can be extracted, even though if the research had been finished much more valuable and reliable scientific information would be obtained.