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Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade

Authors :
Buehler, Leo Hans
Awwad, M
Treter, S
Chang, Q
Basker, M
Alwayn, I P J
Teranishi, K
Ericsson, T
Moran, K
Harper, D
Kurilla-Mahon, B
Huang, C A
Sackstein, R
Sykes, M
White-Scharf, M E
Sachs, D H
Down, J D
Cooper, D K
Source :
Transplantation, Vol. 73, No 1 (2002) pp. 12-22
Publication Year :
2002

Abstract

In an attempt to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, we have infused high-dose porcine peripheral blood progenitor cells (PBPC) into baboons pretreated with a nonmyeloablative regimen and anti-CD154 monoclonal antibody (mAb).

Details

Language :
English
ISSN :
00411337
Database :
OpenAIRE
Journal :
Transplantation, Vol. 73, No 1 (2002) pp. 12-22
Accession number :
edsair.od......1400..c20367c3431a19796f87c300ac6eed11