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Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231
- Source :
- Pharmaceutical Research, Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2009, 26 (4), pp.836-45. ⟨10.1007/s11095-008-9782-1⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; PURPOSE: The aim of this study is to overcome tumour cell resistance that generally develops after administration of commonly used anti-cancer drugs, such as doxorubicin. METHODS: Recently, cell penetrating peptides have been used for their ability to deliver non-permeant compounds into cells. One such cell penetrating peptide, maurocalcine, has been isolated from the venom of a Tunisian scorpion. Herein, we report the effects of doxorubicin covalently coupled to an analogue of maurocalcine on drug-sensitive or drug-resistant cell lines MCF7 and MDA-MB 231. RESULTS: We demonstrated the in vitro anti-tumoral efficacy of the doxorubicin maurocalcine conjugate. On a doxorubicin-sensitive cancer cell line, the maurocalcine-conjugated form appears slightly less efficient than doxorubicin itself. On the contrary, on a doxorubicin-resistant cancer cell line, doxorubicin coupling allows to overcome the drug resistance. This strategy can be generalized to other cell penetrating peptides since Tat and penetratin show similar effects. CONCLUSION: We conclude that coupling anti-tumoral drugs to cell penetrating peptides represent a valuable strategy to overcome drug resistance.
- Subjects :
- drug resistance
[INFO.INFO-BT] Computer Science [cs]/Biotechnology
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
[SDV.CAN] Life Sciences [q-bio]/Cancer
[SDV.CAN]Life Sciences [q-bio]/Cancer
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
[INFO.INFO-BT]Computer Science [cs]/Biotechnology
doxorubicin
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
cell-penetrating peptide
Drug delivery systems
maurocalcine
[SDV.BIO] Life Sciences [q-bio]/Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 07248741 and 1573904X
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Research, Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2009, 26 (4), pp.836-45. ⟨10.1007/s11095-008-9782-1⟩
- Accession number :
- edsair.od......1398..b976934a0895b57f379b8ba7c72f0dd7