Gabapentin (GBP) versus Valproato (VPA) as an adjunct to neuroleptics in the treatment of acute symptoms

This published report yelded promising results, but the interpretations of therapeutic role of GBP in mania was difficult because the drug was always associated to a wide range of other agents, whose dose was not mainteined uncharged during the study. The objective of our study was to asses the efficacy and safety of GBP versus VPA in adjunct of a fixed dose of neuroleptics in patients hospedalized because of an outburst of acute manic symptoms.