First round of focused library for cholera toxin inhibitor search

Authors :: Podlipnik, C
Velter, I
Marcou, G
Belvisi, L
Bernardi, A.
LA FERLA, BARBARA
NICOTRA, FRANCESCO
Podlipnik, C
Velter, I
LA FERLA, B
Marcou, G
Belvisi, L
Nicotra, F
Bernardi, A
Publication Year :: 2007
Publisher :: ELSEVIER SCI LTD, 2007.
Abstract: C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported. © 2007 Elsevier Ltd. All rights reserved.