Gene Polymorphism affecting Alpha-1-Antichymotrypsin and interleukin 1 Plasma Levels increases Alzheimer Disease Risk

Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-IP genes affected plasma levels of ACT or IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype show-ed the highest levels of plasma ACT or IL-1 beta, respectively. The concomitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease