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Identification of transcription factor binding sites in promoter databases

Authors :
Durası, İlknur Melis
Dağ, Uğur
Güngör, Burcu Bakır
Erdoğan, Burcu
Kurnaz, Işıl Aksan
Sezerman, Uğur
Publication Year :
2011
Publisher :
Izmir Institute of Technology, 2011.

Abstract

Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding motifs. Among ETS family TFs, Pea3 proteins are involved in the regulation of expression of genes, which are important for cell growth, development, differentiation, oncogenic transformation and apoptosis. In silico studies should be done to find out the novel target genes for this TF. Even though a few bioinformatics tools are available for this purpose, the user needs to go back and forth between different tools, and to repeat these steps for each of their candidate gene. Here we combined these tools and constituted a new tool which examines the affinity of any TF towards the selected target genes’ promoter sequences. The tool is tested on several genes, which are predicted to be regulated by Pea3 TF.

Subjects

Subjects :
Q Science (General)

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......1246..f089bf3dba559b39c89658cf50392119