PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

Background and purpose: The physiological involvement of endogenous cholecystokinin (CCK) in the termination of feeding has been challenged by evidence of aversive effects of exogenous CCK8. We previously prolonged the anorectic effect of CCK by conjugation to polyethylene glycol (PEGylation) to produce PEG-CCK9. In this study, we investigated the ability of different doses of PEG-CCK9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction. ispartof: British Journal of Pharmacology vol:155 issue:3 pages:417-423 ispartof: location:England status: published