Broad HIV-1 inhibition in vitro by vaccine-elicited CD8+T cells in African adults

Addressing HIV-1 variability is a major scientific challenge, because vaccine-induced immune responses must recognize multiple HIV-1 variants. One approach focuses on conserved HIV-1 sequences that are common to majority of variants and cannot easily mutate. We tested HIV-1 prime-boost vaccine regimens combining conserved regions of HIV-1 (HIVconsv) and full-length clade A Gag-RT-Int-Nef (GRIN).