Anthelmintička učinkovitost nepročišćenog metanolskog iscrpka biljke Xylopia aethiopica protiv oblića Nippostrongylus brasiliensis u štakora

Xylopia aethiopica A. Rich (X. aethiopica; Annonaceae) is used commonly in Nigeria by traditional herbalists and pastoralists to control gastrointestinal helminth parasites. The anthelmintic effect of the crude methanol extract was evaluated in rats experimentally infected with the rat hookworm Nippostrongylus brasiliensis. Thirtyfive rats were each infected subcutaneously with 200 third stage infective larvae of the parasite and randomly grouped into seven groups. Five days after infection, rats in siof the groups were treated with the extract, the dose varying per group. Rats in the seventh (control) group were each given propylene glycol. Anthelmintic activity was assessed by comparing the number of worms recovered from treated rats to those from non-treated infected control rats. The extract at the dose of 0.8 g/kg, 1.0 g/kg, 1.2 g/kg, 1.4 g/kg, 1.7 g/kg and 2.0 g/kg produced deparasitization rates of 21%, 47%, 51%, 50%, 63% and 76% and were signifi cant (P>0.05) when compared to untreated control rats.
Travari i stočari u Nigeriji tradicionalno koriste biljku Xylopia aethiopica protiv želučano crijevnih helminata. Anthelmintički učinak nepročišćenog metanolskog iscrpka istražen je na pokusno invadiranim štakorima oblićem Nippostrongylus brasiliensis. Ukupno 35 štakora podijeljeno je u sedam skupina. Svi štakori supkutano su invadirani s 200 invazijskih ličinki trećeg stupnja. Pet dana nakon invazije, štakorima iz svih šest skupina apliciran je iscrpak u različitim dozama. Štakorima sedme skupine primijenjen je propilen glikol. Učinkovitost je određena uspoređivanjem broja parazita u liječenih i neliječenih štakora. Značajna (P